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What is the charge? Eating a meal, a succulent Chinese meal?

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Nick Tustison

ntustison@virginia.edu

Curriculum Vitae (.pdf)


Education

Professional Appointments

Academic Service

Program committees

2012-present: SPIE Medical Imaging

Editorships

2012-present: Frontiers Review Editorial Board.
May 2013-present: Frontiers in Neuroinformatics: Guest Editor, Neuroinformatics with the Insight ToolKit.

Reviewer Duties

Academic Radiology
American Journal of Neuroradiology
Annals of Biomedical Engineering
Artificial Intelligence in Medicine
Biomedical Signal Processing and Control
Computers in Biology and Medicine
Computerized Medical Imaging and Graphics
Focused Ultrasound Foundation ad hoc grant reviewer
Human Brain Mapping
Image and Vision Computing
International Journal of Pattern Recognition and Artificial Intelligence
IEEE Transactions on Cybernetics
IEEE Transactions on Medical Imaging
IEEE Transactions on Pattern Analysis and Machine Intelligence
IEEE Transactions on Biomedical Engineering
Insight Journal
International Conf. on Medical Image Computing and Computer Assisted Intervention
International Journal of Biomedical Imaging
International Journal of Computer Vision
International Workshop on Medical Imaging and Augmented Reality
IEEE International Symposium on Biomedical Imaging: From Nano to Macro
Journal of Computed Tomography
Journal of Electronic Imaging
Journal of Magnetic Resonance Imaging
Journal of Neurotrauma
Journal of the Optical Society of America A
Magnetic Resonance in Medicine
Medical Physics
Medical Image Analysis
Neurobiology of Aging
NeuroImage
NeuroImage: Clinical
Neuroradiology
Neuroscience and Biobehavioral Reviews
PLOS ONE
Respirology
SIAM Journal on Imaging Sciences

Invited Talks/Participation

Feb. 2012: SPIE Workshop: Medical Imaging, Open source tools for medical image analysis.
Sept. 2012: MICCAI, provided canonical registrations for Grand Challenge and Workshop on Multi-Atlas Labeling.
Sept. 2013: MICCAI, provided canonical registrations for SATA challenge workshop.
May 2015: CREATE-MIA Summer Workshop, ANTs Workshop.
Oct. 2015: MICCAI, SimpleITK tutorial.

Computer Skills

Awards

Areas of research interest

Journal Publications

2017

E. Mortani Barbosa Jr., H. Shou, S. Simpson, N. Tustison, J. Gee, and J.C. Lee, Quantitative CT metrics from the transplanted lung can predict FEV1 after lung transplantation, Journal of Thoracic Imaging. (Accepted)

E. Mortani Barbosa Jr., S. Simpson, J.C. Lee, N. Tustison, J. Gee, and H. Shou, Multivariate modeling using quantitative CT metrics may improve accuracy of diagnosis of bronchiolitis obliterans syndrome after lung transplantation, Computers in Biology and Medicine. (pubmed)

Maurizio Cereda, Yi Xin, Hooman Hamedani, Giacomo Bellani, Stephen Kadlecek, Justin Clapp, Luca Guerra, Natalie Meeder, Jennia Rajaei, Nicholas J. Tustison, James C. Gee Brian P. Kavanagh, and Rahim R. Rizi. Tidal Changes on CT and Progression of ARDS, Thorax. (pubmed)

A. Murat Maga, Nicholas J. Tustison, and Brian B. Avants. A population level atlas of Mus musculus craniofacial skeleton and automated image based shape analysis, Journal of Anatomy, 231(3):433-443, Sep 2017. (pubmed)

Beau Pontré, Brett R. Cowan, Edward DiBella, Sancgeetha Kulaseharan, Devavrat Likhite, Nils Noorman, Lennart Tautz, Nicholas Tustison, Gert Wollny, Alistair A. Young, and Avan Suinesiaputra. An Open Benchmark Challenge for Motion Correction of Myocardial Perfusion MRI, IEEE Journal of Biomedical and Health Informatics, 21(5):1315-1326, Sep 2017. (pubmed)

Amy C. Ladd, David G. Browhan, Ravindar R. Thomas, Paula M. Keeney, Stuart B. Berr, Shaharyar M. Khan, Francisco R. Portell, Meiram Z. Shakenov, Patrick F. Antkowiak, Bijoy Kundu, Nicholas J. Tustison, James P. Bennett, Jr. RNA-seq Analyses Reveal that Cervical Spinal Cords and Anterior Motor Neurons from Amyotrophic Lateral Sclerosis Subjects Show Reduced Expression of Mitochondrial DNA-Encoded Respiratory Genes, and rhTFAM May Correct This Respiratory Deficiency, Brain Research 1667:74-83, Jul 2017. (pubmed)

Talissa A. Altes, Mac Johnson, Meredith Fidler, Martyn Botfield, Nicholas J. Tustison, Carlos Leiva-Salinas, Eduard E. de Lange, Deborah Froh, and John P. Mugler III. Use of hyperpolarized helium-3 MRI to assess response to ivacaftor treatment in patients with cystic fibrosis, Journal of Cystic Fibrosis, 16(2):267-274, Mar 2017. (pubmed)

2016

Elisabeth A. Wilde, Erin D. Bigler, Trevor J. Huff, Haonan Wang, Garrett M. Black, Zachary Christensen, Naomi Goodrich-Hunsaker, Jo Ann Petrie, Tracy Abildskov, Brian A. Taylor, James R. Stone, Nicholas J. Tustison, Mary R. Newsome, Harvey S. Levin, Zili D. Chu, Gerald E. York, David F. Tate. Quantitative Structural Neuroimaging of Mild Traumatic Brain Injury in the Chronic Effects of Neurotrauma Consortium (CENC): Comparison of Volumetric Data within and across Scanners, Brain Injury, 30(12):1442-1451, 2016. (pubmed)

James R. Stone, Elisabeth A. Wilde, Brian A. Taylor, David F. Tate, Harvey Levin, Erin D. Bigler, Randall S. Scheibel, Mary R. Newsome, Andrew R. Mayer, Tracy Abildskov, Garrett M. Black4, Michael J. Lennon, Gerald E. York, Rajan Agarwal, Jorge DeVillasante, John L. Ritter, Peter B. Walker, Stephen T. Ahlers, and Nicholas J. Tustison. Supervised learning technique for the automated identification of white matter hyperintensities in traumatic brain injury, Brain Inury, 30(12):1458-1468, 2016. (pubmed)

Lucia Flors, John P. Mugler, Eduard E. De Lange, Grady W. Miller, Jaime F. Mata, Nick Tustison, Iulian C. Ruset, William W. Hersman, and Talissa A. Altes. Hyperpolarized Gas Magnetic Resonance Lung Imaging in Children and Young Adults, J Thorac Imaging, 31(5):285-95, Sep 2016. (pubmed)

Anthony J. Filiano, Yang Xu, Nicholas J. Tustison, Rachel L. Marsh, Wendy Baker, Igor Smirnov, Christopher C. Overall, Sachin P. Gadani, Stephen D. Turner, Zhiping Weng, Sayeda Najamussahar Peerzade, Hao Chen, Kevin S. Lee, Michael M. Scott, Mark P. Beenhakker, Vladimir Litvak, and Jonathan Kipnis. Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour, Nature, 535(7612):425-9, Jul 2016. (pubmed)

Nicholas J. Tustison, Kun Qing, Chengbo Wang, Talissa A. Altes, John P. Mugler III. Atlas-based estimation of lung and lobar anatomy in proton MRI. Magn Reson Med, 76(1):315-20, Jul 2016. (pubmed)

Genevera I Allen, Nicola Amoroso, Catalina Anghel, Venkat Balagurusamy, Christopher J Bare, Derek Beaton, Roberto Bellotti, David A Bennett, Kevin Boehme, Paul C Boutros, Laura Caberlotto, Cristian Caloian, Frederick Campbell, Elias Chaibub Neto, Yu- Chuan Chang, Beibei Chen, Chien-Yu Chen, Ting-Ying Chien, Tim Clark, Sudeshna Das, Christos Davatzikos, Jieyao Deng, Donna Dillenberger, Richard JB Dobson, Qilin Dong, Jimit Doshi, Denise Duma, Rosangela Errico, Guray Erus, Evan Everett, David W Fardo, Stephen H Friend, Holger Fröhlich, Jessica Gan, Peter St George-Hyslop, Satrajit S Ghosh, Enrico Glaab, Robert C Green, Yuanfang Guan, Ming-Yi Hong, Chao Huang, Jinseub Hwang, Joseph Ibrahim, Paolo Inglese, Qijia Jiang, Yuriko Katsumata, John SK Kauwe, Arno Klein, Dehan Kong, Roland Krause, Emilie Lalonde, Mario Lauria, Eunjee Lee, Xihui Lin, Zhandong Liu, Julie Livingstone, Benjamin A Logsdon, Simon Lovestone, Anandhi Lyappan, Michelle Ma, Ashutosh Malhotra, Lara M Mangravite, Taylor J Maxwell, Emily Merrill, John Nagorski, Aishwarya Namasivayam, Manjari Narayan, Mufassra Naz, Stephen J Newhouse, Thea C Norman, Ramil N Nurtdinov, Yen-Jen Oyang, Yudi Pawitan, Shengwen Peng, Mette A Peters, Stephen R Piccolo, Paurush Praveen, Corrado Priami, Veronica Y Sabelnykova, Philipp Senger, Xia Shen, Andrew Simmons, Aristeidis Sotiras, Gustavo Stolovitzky, Sabina Tangaro, Andrea Tateo, Yi-An Tung, Nicholas J Tustison, Erdem Varol, George Vradenburg, Michael W Weiner, Guanghua Xiao, Lei Xie, Yang Xie, Jia Xu, Hojin Yang, Xiaowei Zhan, Yunyun Zhou, Fan Zhu, Hongtu Zhu, Shanfeng Zhu, Alzheimer’s Disease Neuroimaging Initiative. Crowdsourced estimation of cognitive decline and resilience in Alzheimer’s disease. Alzheimers Dement, 12(6):645-53, Jun 2016. (pubmed)

Khader M. Hasan, Benson Mwangi, Bo Cao, Zafer Keser, Nicholas J. Tustison, Peter Kochunov, Richard E. Frye, Mirjana Savatic, Jair Soares. Entorhinal cortex thickness across the human lifespan. J of Neuroimaging, 26(3):278-82, May 2016. (pubmed)

Dorian Pustina, Branch H Coslett, Peter E Turkeltaub, Nicholas Tustison, Myrna F Schwartz, and Brian Avants. Automated segmentation of chronic stroke lesions using LINDA: Lesion Identification with Neighborhood Data Analysis, Hum Brain Mapp, 37(4):1405-21, Apr 2016. (pubmed)

Talissa A. Altes, John P. Mugler III, Kai Ruppert, Nicholas J. Tustison, Joanne Gersbach, Sylvia Szentpetery, Craig H. Meyer, Eduard E. de Lange, and W. Gerald Teague. Clinical Correlates of Lung Ventilation in Asthmatic Children. J Allergy Clin Immun, 137(3):789-796, Mar 2016. (pubmed)

2015

Kun Qing, Talissa A. Altes, Nicholas J. Tustison, Xue Feng, Xiao Chen, Jaime F. Mata, G. Wilson Miller, Eduard E. de Lange, William A. Tobias, Gordon D. Cates, Jr., James R. Brookeman, John P. Mugler, III. Rapid Acquisition of Helium-3 and Proton 3D Image Sets of the Human Lung in a Single Breath-hold using Compressed Sensing. Magn Reson Med, 74(4):1110-5, Oct 2015. (pubmed)

Bjoern H. Menze, Andras Jakab, Stefan Bauer, Jayashree Kalpathy-Cramer, Keyvan Farahani, Justin Kirby, Yuliya Burren, Nicole Porz, Johannes Slotboom, Roland Wiest, Levente Lanczi, Elizabeth Gerstner, Marc-Andre Weber, Tal Arbel, Brian B. Avants, Nicholas Ayache, Patricia Buendia, D. Louis Collins, Nicolas Cordier, Jason J. Corso, Antonio Criminisi, Tilak Das, Herve ́ Delingete, Cagatay Demiralp, Christopher R. Durst, Michel Dojat, Senan Doyle, Joana Festa, Florence Forbes, Ezequiel Geremia, Ben Glocker, Polina Golland, Xiaotao Guo, Andac Hamamci, Khan M. Iftekharuddin, Raj Jena, Nigel M. John, Ender Konukoglu, Danial Lashkari, Jose Antonio Mariz, Raphael Meier, Sergio Pereira, Doina Precup, S. J. Price, Tammy Riklin-Raviv, Syed M. S. Reza, Michael Ryan, Lawrence Schwartz, Hoo-Chang Shin, Jamie Shotton, Carlos A. Silva, Nuno Sousa, Nagesh K. Subbanna, Gabor Szekely, Thomas J. Taylor, Owen M. Thomas, Nicholas J. Tustison, Gozde Unal, Flor Vasseur, Max Wintermark, Dong Hye Ye, Liang Zhao, Binsheng Zhao, Darko Zikic, Marcel Prastawa, Mauricio Reyes, and Koen Van Leemput. The Multimodal Brain Tumor Image Segmentation Benchmark (BRATS). IEEE Trans Med Imaging, 34(10):1993-2024, Oct 2015. (pubmed)

CR Durst, N Michael, NJ Tustison, JT Patrie, P Raghavan, M Wintermark, SS Velan. Noninvasive Evaluation of the Regional Variations of GABA using Magnetic Resonance Spectroscopy at 3 Tesla. Magn Reson Imaging, 33(5):611-7, June 2015. (pubmed)

Nicholas J. Tustison, K. L. Shrinhidi, Max Wintermark, Christopher R. Durst, Benjamin M. Kandel, James C. Gee, Murray C. Grossman, and Brian B. Avants. Optimal symmetric multimodal templates and concatenated random forests for supervised brain tumor segmentation (simplified) with ANTsR. Neuroinformatics, 13(2):209-225, April 2015. (pubmed)

Brian B. Avants, Hans J. Johnson, Nicholas J. Tustison. Neuroinformatics and the Insight ToolKit. Front Neuroinform, 9:5, March 2015. (pubmed)

Yi Xin, Gang Song, Maurizio Cereda, Stephen Kadlecek, Hooman Hamedani, Yunqing Jiang, Jennia Rajaei, Justin Clapp, Harrilla Profka, Natalie Meeder, Jue Wu, Nicholas Tustison, James Gee, and Rahim Rizi. Semi-Automatic Segmentation of Longitudinal Computed Tomography Images in a Rat Model of Lung Injury by Surfactant Depletion. J Appl Physiol, 118(3):377-85, Feb 2015. (pubmed)

Brian Avants, Jeffrey Duda, Emily Kilroy, Kay Jann, Benjamin Kandel, Lirong Yan, Mayank Jog, Nicholas Tustison, Robert Smith, Yi Wang, Kate Krasileva, Mirella Rapretto, and Danny Wang. The Pediatric Template of Brain Perfusion, Scientific Data, Feb 2015. (pubmed)

2014

Jonathon H Yoder, John M Peloquin, Gang Song, Nicholas J Tustison, Sung M Moon, Alexander C Wright, Edward J Vresilovic, James C Gee, Dawn M Elliott. Internal Human Intervertebral Disc 3D Strains Under Axial Compression Quantified Non-invasively with MRI and Image Registration. J Biomech Eng, 136(11), Nov 2014. (pubmed)

Nicholas Said, W. Jeff Elias, Prashant Raghavan, Alan Cupino, Nicholas Tustison, Robert Frysinger, James Patrie, Wenjun Xin, Max Wintermark. Correlation of Diffusion Tensor Tractography and Intraoperative Macro-Stimulation during Deep Brain Stimulation for Parkinson’s Disease. J Neurosurg, 25:1-7, Jul 2014. (pubmed)

Nicholas J. Tustison, Philip A. Cook, Arno Klein, Gang Song, Sandhitsu R. Das, Jeffrey T. Duda, Benjamin M. Kandel, Niels van Strien, James R. Stone, James C. Gee, and Brian B. Avants. Large-Scale Evaluation of ANTs and FreeSurfer Cortical Thickness Measurements. NeuroImage, 99:166-179, Oct 2014. (pubmed)

Max Wintermark, Nicholas J Tustison, William J Elias, James T Patrie, Wenjun Xin, Nicholas Demartini, Matt Eames, Suna Sumer, Benison Lau, Alan Cupino, John Snell, Arik Hananel, Neal Kassell, and Jean-Francois Aubry. T1-weighted MRI as a substitute to CT for refocusing planning in MR-guided focused ultrasound. Phys Med Biol, 59(13):3599-614, July 2014. (pubmed)

W. Gerald Teague, Nicholas J. Tustison, and Talissa A. Altes. Ventilation Heterogeneity in Asthma. Journal of Asthma, 13:1-30, May 2014. (pubmed)

Brian B. Avants, Nicholas J. Tustison, Michael Stauffer, Gang Song, Baohua Wu, and James C. Gee. The Insight ToolKit Image Registration Framework. Front Neuroinform, 8:44. (pubmed)

Max Wintermark, Diane S. Huss, Binit B. Shah, Nicholas J. Tustison, T. Jason Druzgal, Neal Kassell, and Jeff Elias. Thalamic Connectivity in Patients with Essential Tremor Treated with MR Imaging-guided Focused Ultrasound: In Vivo Fiber Tracking by Using Diffusion-Tensor MR Imaging. Radiology, 272(1):202-9, Jul 2014. (pubmed)

Nicholas J Tustison, Brian B Avants, Philip A Cook, Junghoon Kim, John Whyte, James C Gee, and James R Stone. Logical circularity in voxel-based analysis: Normalization strategy may induce statistical bias. Hum Brain Mapp, 35:745–759, Mar 2014. (pubmed)

Christopher R Durst, Prashant Raghavan, Mark E Shaffrey, David Schiff, M Beatriz Lopes, Jason P Sheehan, Nicholas J Tustison, James T Patrie, Wenjun Xin, W Jeff Elias, Kenneth C Liu, Greg A Helm, A Cupino, and Max Wintermark. Multimodal MR imaging model to predict tumor infiltration in patients with gliomas. Neuroradiology, 56(2):107-15, Feb 2014. (pubmed)

2013

Nicholas J. Tustison and Brian B. Avants. Explicit B-spline regularization in diffeomorphic image registration. Front Neuroinform, 7:39, 2013. (pubmed)

Nicholas J Tustison, Hans J Johnson, Torsten Rohlfing, Arno Klein, Satrajit S Ghosh, Luis Ibanez, and Brian B Avants. Instrumentation bias in the use and evaluation of scientific software: recommendations for reproducible practices in the computational sciences. Front Neurosci, 7:162, 2013. (pubmed)

2012

Gang Song, Eduardo Mortani Barbosa, Jr, Nicholas Tustison, Warren B Gefter, Maryl Kreider, James C Gee, and Drew A Torigian. A comparative study of HRCT image metrics and PFT values for characterization of ILD and COPD. Acad Radiol, 19(7):857–64, Jul 2012. (pubmed)

2011

Brian B Avants, Nicholas J Tustison, Jue Wu, Philip A Cook, and James C Gee. An open source multivariate framework for n-tissue segmentation with evaluation on public data. Neuroinformatics, 9(4):381–400, Dec 2011. (pubmed)

Keelin Murphy, Bram van Ginneken, Joseph M Reinhardt, Sven Kabus, Kai Ding, Xiang Deng, Kunlin Cao, Kaifang Du, Gary E Christensen, Vincent Garcia, Tom Vercauteren, Nicholas Ayache, Olivier Commowick, Grégoire Malandain, Ben Glocker, Nikos Paragios, Nassir Navab, Vladlena Gorbunova, Jon Sporring, Marleen de Bruijne, Xiao Han, Mattias P Heinrich, Julia A Schnabel, Mark Jenkinson, Cristian Lorenz, Marc Modat, Jamie R McClelland, Sébastien Ourselin, Sascha E A Muenzing, Max A Viergever, Dante De Nigris, D Louis Collins, Tal Arbel, Marta Peroni, Rui Li, Gregory C Sharp, Alexander Schmidt-Richberg, Jan Ehrhardt, René Werner, Dirk Smeets, Dirk Loeckx, Gang Song, Nicholas Tustison, Brian Avants, James C Gee, Marius Staring, Stefan Klein, Berend C Stoel, Martin Urschler, Manuel Werlberger, Jef Vandemeulebroucke, Simon Rit, David Sarrut, and Josien P W Pluim. Evaluation of registration methods on thoracic CT: the EMPIRE10 challenge. IEEE Trans Med Imaging, 30(11):1901–20, Nov 2011. (pubmed)

Eduardo Mortani Barbosa, Jr, Gang Song, Nicholas Tustison, Maryl Kreider, James C Gee, Warren B Gefter, and Drew A Torigian. Computational analysis of thoracic multidetector row HRCT for segmentation and quantification of small airway air trapping and emphysema in obstructive pulmonary disease. Acad Radiol, 18(10):1258–69, Oct 2011. (pubmed)

Nicholas J Tustison, Brian B Avants, Lucia Flors, Talissa A Altes, Eduard E de Lange, John P Mugler, 3rd, and James C Gee. Ventilation-based segmentation of the lungs using hyperpolarized (3)he MRI. J Magn Reson Imaging, 34(4):831–41, Oct 2011. (pubmed)

Cuneyt Yilmaz, Nicholas J Tustison, D Merrill Dane, Priya Ravikumar, Masaya Takahashi, James C Gee, and Connie C W Hsia. Progressive adaptation in regional parenchyma mechanics following extensive lung resection assessed by functional computed tomography. J Appl Physiol, 111(4):1150–8, Oct 2011. (pubmed)

Nicholas J Tustison, Brian B Avants, Marcelo Siqueira, and James C Gee. Topological well-composedness and glamorous glue: a digital gluing algorithm for topologically constrained front propagation. IEEE Trans Image Process, 20(6):1756–61, Jun 2011. (pubmed)

Nicholas J Tustison, Tessa S Cook, Gang Song, and James C Gee. Pulmonary kinematics from image data: a review. Acad Radiol, 18(4):402–17, Apr 2011. (pubmed)

Brian B Avants, Nicholas J Tustison, Gang Song, Philip A Cook, Arno Klein, and James C Gee. A reproducible evaluation of ANTs similarity metric performance in brain image registration. Neuroimage, 54(3):2033–44, Feb 2011. (pubmed)

Nicholas J Tustison, Suyash P Awate, Gang Song, Tessa S Cook, and James C Gee. Point set registration using Havrda-Charvat-Tsallis entropy measures. IEEE Trans Med Imaging, 30(2):451–60, Feb 2011. (pubmed)

2010

Nicholas J Tustison, Talissa A Altes, Gang Song, Eduard E de Lange, John P Mugler, 3rd, and James C Gee. Feature analysis of hyperpolarized helium-3 pulmonary MRI: a study of asthmatics versus nonasthmatics. Magn Reson Med, 63(6):1448–55, Jun 2010. (pubmed)

Nicholas J Tustison, Brian B Avants, Philip A Cook, Yuanjie Zheng, Alexander Egan, Paul A Yushkevich, and James C Gee. N4ITK: improved N3 bias correction. IEEE Trans Med Imaging, 29(6):1310–20, Jun 2010. (pubmed)

Nicholas J Tustison, Suyash P Awate, Jing Cai, Talissa A Altes, G Wilson Miller, Eduard E de Lange, John P Mugler, 3rd, and James C Gee. Pulmonary kinematics from tagged hyperpolarized helium-3 MRI. J Magn Reson Imaging, 31(5):1236–41, May 2010. (pubmed)

2009

Nicholas J Tustison, Brian B Avants, and James C Gee. Directly manipulated free-form deformation image registration. IEEE Trans Image Process, 18(3):624–35, Mar 2009. (pubmed)

2008

Marcelo Siqueira, Longin J. Latecki, Nicholas J. Tustison, J. Gallier, and James C. Gee. Topological repairing of 3D digital images. J Math Imaging Vis, 30(3):249–274, March 2008.

2006

Nicholas J. Tustison and Amir A. Amini. Biventricular myocardial strains via nonrigid registration of anatomical NURBS model [corrected]. IEEE Trans Med Imaging, 25(1):94–112, Jan 2006. (pubmed)

2003

Nicholas J Tustison, Victor G Dávila-Román, and Amir A Amini. Myocardial kinematics from tagged MRI based on a 4-D B-spline model. IEEE Trans Biomed Eng, 50(8):1038–40, Aug 2003. (pubmed)

2000

K D Hagspiel, T A Altes, J P Mugler, 3rd, M J Spellman, Jr, J F Mata, N J Tustison, and J R Brookeman. MR virtual colonography using hyperpolarized (3)He as an endoluminal contrast agent: demonstration of feasibility. Magn Reson Med, 44(5):813–6, Nov 2000. (pubmed)